The EPA found Diazinon highly toxic to birds and banned its use in such areas as golf courses. Diazinon can cause cholinesterase inhibition in humans; that is, it can overstimulate the nervous system causing nausea, dizziness, confusion, and at very high exposures (e.g. The phase-out of Diazinon pest products actually began in 1988, after large quantities of mass bird kills were linked to Diazinon treatments in large open areas. diazinon’s toxicological effects stem from its inhibition of AChE. After the Environmental Protection Agency (EPA) banned the pesticides diazinon and dursban because of health concerns for humans and wildlife, they continued to be used until stockpiles ran out. Its biological fate is complex, mediated largely by diverse metabolic mechanisms. 2.1.2.4. December 2010 – Report on Air Monitoring of an Orchard Application of Diazinon in Glenn County during January 2010 Body systems affected by diazinon. Why Banned Toxic Substances Diazinon & Dursban are Still In Use Today: An Interview with Environment by www.SixWise.com. accidents or major spills) respiratory paralysis and death. For example, an enzyme involved in the metabolism of the amino acid tryptophan is strongly in-hibited by diazinon … The reason that EPA does not accept this type of human study is clear: in order to determine the dose that produces no effect, test animals, in this case humans, must be exposed to doses of the pesticide that cause toxic effects. Diazinon and other organophosphates inhibit numer-ous enzymes with molecular structures that are similar to AChE. July 1994 – ; Preliminary Human Pesticide Exposure Assessment (For Use on Residential Turf and Soil) (PDF) Other Documents. Diazinon SAFETY DATA SHEET 11.1 CAS # Hazardous Components (Chemical Name) NTP Section 11. Risk Characterization Documents (RCDs) estimate the nature and likelihood of adverse health effects in humans who may be exposed to pesticides. Diazinon - Toxicity Data: Oral TDLO (human): 214 mg/kg; Oral LD50 (rat): 66 mg/kg; Diazinon is an insecticide, a product used to kill or control bugs. Diazinon is readily absorbed by inhalation, ingestion and skin penetration. It is associated with an increased risk of brain cancer in children and the … Toxicological Information The toxicological effects of this product have not been thoroughly studied. Poisoning can occur if you swallow diazinon. Health Effects. A no effect level is the stepping stone from which the agency determines a safe exposure dose. Diazinon is also detrimental to aquatic plants, algae and sediment residing organisms. Likewise, diazinon highly toxic to birds, mammals and other beneficial animals such as honeybees and earthworms. Risks Apart from kidney and liver where diazinon metabolites predominated, most of the radioactivity (56-85%) present in these tissues was associated with unchanged diazinon (Capps, 1990 with an amendment by Carlin, 1994). This is for information only and not for use in the … Diazinon exhibits high acute toxicity to a wide variety of animals, leading to a wide range of sublethal biochemical effects, damage to specific target organs and tissues, cytotoxic and genotoxic effects, reproductive damage, and adverse ecological impacts. Tissue distribution In male Yok:ddY outbred strain mice, kidney, liver and brain concentrations of diazinon after Diazinon is particularly detrimental to both the respiratory tract and the central nervous system. EPA’s own data show that diazinon is a potent nerve poison responsible for numerous human poisonings and deaths. , diazinon highly toxic to birds, mammals and other beneficial animals such honeybees. By inhalation, ingestion and skin penetration Turf and Soil ) ( PDF ) other Documents central... 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